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个人简介
Five outstanding areas of accomplishment (among many) come to mind. First, Bill was a leader in uncovering the role of oxidative stress and free radical biology in neurodegenerative diseases, including in lipids, proteins, and nucleic acids. With his colleagues at UK and elsewhere, he also emphasized the importance of the concept of preclinical AD. He recognized from his clinical patient care and his view through the microscope that cognitive dysfunction in aging humans is often multifactorial, and that these brain diseases often exist in a complex mixture in the brain. In the interim, he joined several of his colleagues and helped to craft the Consensus Recommendations for the Postmortem Diagnosis of AD in 1997. Finally, Bill led the charge with his UK colleagues and volunteers in acknowledging the need for rigorous data management, quantitative neuropathology, and building community trust in conducting longitudinal studies on brain aging (as epitomized in his work on the Georgia Centenarian, Religious Orders, Nun, and Biologically Resilient Older Adults in Neurological Studies projects).
研究兴趣
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Alzheimer’s Diseasepp.111-124, (2019)
Neurobiology of agingno. 1 (2012): 205.e1-18
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