My research involves work on identifying gene regulatory and biochemical networks for fundamental biological processes in fungal systems and validating these biological circuits by fitting them to genomics data. Since the discovery of the structure of DNA, biologists have been taking apart living systems on a finer and finer scale until we have been able to determine the complete genetic blueprint of many organisms. The challenge of the new millennium is "reassembling the pieces", i.e., moving from genomes to life. One approach to reassembling the pieces is to borrow a metaphor from computer science: the entire chemical reaction network describing what a cell does is a biological circuit. The theme for the genomics and computational biology part of my research is “computing life”, i.e., identifying biological circuits for fundamental processes like carbon metabolism and validating these biological circuits by fitting them to genomics data describing what the cell is doing (i.e., RNA and protein profiling data)