Pre-vaccination and early B cell signatures predict antibody response to SARS-CoV-2 mRNA vaccine

Lela Kardava,Nicholas Rachmaninoff,Lau Ww, Buckner Cm,Krittin Trihemasava, de Assis Fl,W Wang,X Zhang,Y Wang, Cheng Feng Chiang,Sandeep Narpala,Robert Reger, McCormack Ge, Seamon Ca, Childs Rw, A. F. Suffredini, Strich, Chertow Ds, Davey Rt, Sneller Mc, Sarah O’Connell,Li Y,Adrian B. McDermott,Tae‐Wook Chun, Fauci As, Tsang Js,Susan Moir

medRxiv (Cold Spring Harbor Laboratory)(2021)

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摘要
Abstract SARS-CoV-2 mRNA vaccines are highly effective, although weak antibody responses are seen in some individuals with correlates of immunity that remain poorly understood. Here we longitudinally dissected antibody, plasmablast, and memory B cell (MBC) responses to the two-dose Moderna mRNA vaccine in SARS-CoV-2-uninfected adults. Robust, coordinated IgA and IgG antibody responses were preceded by bursts of spike-specific plasmablasts after both doses, but earlier and more intensely after dose two. Distinct antigen-specific MBC populations also emerged post-vaccination with varying kinetics. We identified antigen non-specific pre-vaccination MBC and post-vaccination plasmablasts after dose one and their spike-specific counterparts early after dose two that correlated with subsequent antibody levels. These baseline and response signatures can thus provide early indicators of serological efficacy and explain response variability in the population.
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关键词
vaccine,antibody response,pre-vaccination,sars-cov
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