Dietary a novel structured lipid synthesized by soybean oil and coconut oil alter fatty acid metabolism in C57BL/6J mice

The rising obesity rate underpins the increasing incidences of many chronic diseases, which are associated with substantial mortality worldwide. The changes of specific fatty acids in lipid profiles and its association with anti-obesity are not entirely clear. The purpose of this study was to determine the fatty acid metabolism of a novel structured lipid prepared from soybean oil and coconut oil in C57BL/6J mice. The lipid digestion rate of SLs was higher than physical blend (SOCO) and soybean oil on in vitro digestion model. The conversion of essential FAs (18:2n-6 and 18:3n-3), oxidation of saturated FAs in the liver, and the digestion and absorption of saturated FAs in the intestine increased with increasing SLs content. In addition, the mRNA expression of hepatic beta-oxidation genes (PPAR alpha and ACO), was higher in the SLs diet groups than in the HFD group, whereas the mRNA expression of lipogenesis genes (SREBP-1c, ACC-1, SCD-1 and FAS) showed the opposite trend. It is concluded that prepared structured lipids can use as one kind of functional oils to resist obesity.