Deficiency for the Metalloproteinase Meprin 1-Beta Enhances Severity of, and Delays Recovery From Acute DSS Colitis

of local inflammatory signals to develop gut antigen-specific Th17 and Treg cells that may be found systemically after the resolution of inflammation.These insights will ultimately help elucidate how the gut environment and pathogen-associated molecular patterns steer the development of adaptive immune responses during colitis and how pathogen-recognition receptors can be used to manipulate the development or resolution of inflammation to treat gastrointestinal disease.