Retinoic Acid Controlled Cyclooxygenase-2 Mediates Induction Of Regulatory T-Cells In The Intestine

CD4+CD25-cells as shown by weight loss, and endoscopy/histological signs of inflammation.Moreover mice receiving either wild type or Smad7 transgenic CD4+CD25-cells developed colitis, but this was more severe in the latter.Analysis of inflammatory cytokines in the colon of mice revealed high IFN-gamma and low IL-17 in mice reconstituted with Smad7tg CD4+CD25-T cells.Conclusions: High Smad7 makes T cells resistant to the CD4+CD25+T cell-mediated immunesuppression thereby worsening T cell-dependent intestinal inflammation.