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Increased TMEM106B Levels Lead to Lysosomal Dysfunction Which Affects Synaptic Signaling and Neuronal Health

Jolien Perneel, Miranda Lastra Osua, Sara Alidadiani, Nele Peeters, Linus De Witte,Bavo Heeman, Simona Manzella,Riet De Rycke, Mieu Brooks, Ralph B. Perkerson, Elke Calus,Wouter De Coster,Manuela Neumann,Ian R. A. Mackenzie,Debby Van Dam,Bob Asselbergh,Tommas Ellender,Xiaolai Zhou,Rosa Rademakers

Molecular Neurodegeneration（2025）

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Key words
TMEM106B,Mouse model,Lysosomal dysfunction,Neuronal activity,Synaptic signaling
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