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Development of Cyclopeptide Inhibitors Specifically Disrupting FXR-coactivator Interaction in the Intestine As a Novel Therapeutic Strategy for MASH.

Yazhou Li, Tingying Jiao,Xi Cheng, Lu Liu, Mengjiao Zhang,Jian Li,Jue Wang, Shulei Hu, Cuina Li,Tao Yu, Yameng Liu, Yangtai Li, Yu Zhang, Chuying Sun, Jina Sun,Jiang Wang,Cen Xie,Hong Liu

Life metabolism(2025)

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Key words
intestine-targeted drugs,FXR antagonists,cyclopeptide,metabolic dysfunction-associated steatohepatitis,protein-protein interactions
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