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Improved CAR Internalization and Recycling Through Transmembrane Domain Optimization Reduces CAR-T Cytokine Release and Exhaustion

Shufeng Xie, Jinlan Long, Ruiheng Wang, Rufang Xiang, Huajian Xian,Yixin Wang, Weiyu Dou,Wenjie Zhang,Dan Li,Ting Kang,Zhihong Chen,Chunjun Zhao,Zhenshu Xu,Han Liu

Frontiers in immunology（2025）

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Key words
car-t,transmembrane domain,internalization,recycling,exhaustion,cytokine release
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