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Highly Synergistic Eradication of 143B Osteosarcoma Cells in Vitro by the Combination of Recombinant Methioninase, Chloroquine, and Rapamycin Targeting Methionine Addiction, Autophagy, and Mtor, Respectively.

Sei Morinaga,Qinghong Han,Kohei Mizuta,Byung Mo Kang,Michael Bouvet,Norio Yamamoto,Katsuhiro Hayashi,Hiroaki Kimura,Shinji Miwa,Kentaro Igarashi,Takashi Higuchi,Hiroyuki Tsuchiya,Satoru Demura,Robert M Hoffman

Anticancer research（2025）

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