Cooperative Hedgehog/GLI and JAK/STAT Signaling Drives Immunosuppressive Tryptophan/kynurenine Metabolism Via Synergistic Induction of IDO1 in Skin Cancer.

Dominik P. Elmer,Georg Stockmaier,Sandra Grund-Gröschke, Victoria Strobl,Hieu-Hoa Dang,Markus Wiederstein,David Licha,Anna Strobl, Anna Eglseer,Christina Sternberg,Suzana Tesanovic,Wolfgang Gruber,Florian Wolff,Richard Moriggl,Angela Risch,Roland Reischl,Christian G. Huber,Peter W. Krenn,Nikolaus Fortelny,Jutta Horejs-Hoeck,Fritz Aberger

Cell Communication and Signaling（2025）

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Key words

Hedgehog signaling,Skin cancer,GLI transcription factors,Immune evasion,Indoleamine 2,3-dioxygenase 1,Interleukin 6,Interferon gamma,Signal Transducer and activator of transcription (STAT) proteins

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