Targeting BCL11B in CAR-engineered Lymphoid Progenitors Drives NK-like Cell Development with Prolonged Anti-Leukemic Activity

Franziska Baatz, Arnab Ghosh,Jessica Herbst,Saskia Polten,Johann Meyer,Manuel Rhiel,Tobias Maetzig,Robert Geffers,Michael Rothe, Antonella Lucia Bastone,Philipp John-Neek, Jörg Frühauf,Britta Eiz-Vesper,Agnes Bonifacius,Christine S. Falk, Constantin v. Kaisenberg,Toni Cathomen,Axel Schambach,Marcel R.M. van den Brink,Michael Hust

Molecular Therapy（2025）

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关键词

hematopoietic stem cell transplantation,lymphoid progenitors,BCL11B,gene editing,NK cell differentiation,adoptive immunotherapy,acute myeloid leukemia

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