Single-cell RNA Sequencing Identifies Molecular Biomarkers Predicting Late Progression to CDK4/6 Inhibition in Patients with HR+/HER2- Metastatic Breast Cancer

Linjie Luo,Peng Yang,Sofia Mastoraki,Xiayu Rao,Yan Wang,Nicole M. Kettner,Akshara Singareeka Raghavendra,Debasish Tripathy,Senthil Damodaran,Kelly K. Hunt, Jing Wang,Ziyi Li,Khandan Keyomarsi

Molecular Cancer（2025）

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Key words

CDK4/6 inhibitor,Drug resistance,Metastatic breast cancer,Outcome prediction,Predictive biomarker,Single-cell RNA-sequencing,Target therapy,Transcriptomics,Tumor microenvironment,Tumor-infiltrating lymphocytes

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