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Rational Design of a Potent, Selective, and Metabolically Stable CDK9 Inhibitor to Counteract Osimertinib Resistance Through Mcl-1 Suppression and Enhanced BRD4 Co-Targeting.

Tizhi Wu, Jiali Huang, Xiankang Zhang,Feihai Ma, Shijing Yu, Yifang Liu, Yifan Xu, Shiqi Wu,Alexander V Finko,Zhiyu Li, Li Feng,Jinlei Bian

Journal of medicinal chemistry（2025）

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