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A Potent Epigenetic Editor Targeting Human PCSK9 for Durable Reduction of Low-Density Lipoprotein Cholesterol Levels

Frederic Tremblay, Qiang Xiong, Shrijal S. Shah,Chih-Wei Ko, Kenneth Kelly, Mary S. Morrison, Cristiana Giancarlo,Ricardo N. Ramirez, Erica M. Hildebrand, Sarah B. Voytek, Gabriel K. El Sebae, Shane H. Wright, Liam Lofgren,Scott Clarkson, Christine Waters, Samantha J. Linder, Songlei Liu, Taesun Eom, Shefal Parikh, Yuki Weber, Salette Martinez,Padma Malyala,Sahar Abubucker,Ari E. Friedland,Morgan L. Maeder,Angelo Lombardo,Vic E. Myer, Aron B. Jaffe

NATURE MEDICINE(2025)

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