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Design, Synthesis, and Evaluation of Carboxylic Acid-Substituted Celecoxib Isosteres As Potential Anti-Inflammatory Agents

Zi-Jie Song, Xiao-Fei Wu, Zhi-Ya Zhou,Jing-Jing Zhang, Yan-Yan Pan,Xue Dong,Xuan Pang, Ya-Ping Xie,Juan Sun,Yu Zhang,Jie Qin

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY(2025)

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Key words
Carboxylic acid,Celecoxib isosteric derivative,Anti-inflammatory activity,Selective COX-2 inhibitor,Molecular docking
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