IgA Class Switching Enhances Neutralizing Potency Against SARS-CoV-2 by Increased Antibody Hinge Flexibility

Mengxin Xu, Zhaoyong Zhang, Yuzhu Sun,Haoting Mai,Siqi Liu, Shuning Liu, Kexin Lv, Feiyang Yu,Yuanyuan Wang, Xinyu Yue, Jiayi Zhang, Xiaoyu Cai, Ruixin Zhao, Hongjie Lu,Lin Liu,Huanle Luo, Haiyan Zhao,Yanqun Wang,Peng Gong,Shoudeng Chen, Xuping Jing,Jincun Zhao,Yao-Qing Chen

ANTIVIRAL RESEARCH（2025）

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Key words

Immunoglobulin A (IgA),Immunoglobulin G (IgG),Class switching,Neutralization enhancement,Antibody hinge

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