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Multi-Targeting Macrocyclic Peptides As Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of Α-Synuclein

Simon Hornung, Dominik P. Vogl,Denise Naltsas,Beatrice Dalla Volta,Markus Ballmann, Beatrice Marcon,Muhammed Muazzam Kamil Syed, Yiyang Wu,Anna Spanopoulou,Regina Feederle, Luzia Heidrich,Juergen Bernhagen,Thomas Koeglsperger, Guenter U. Hoeglinger,Gerhard Rammes,Hilal A. Lashuel,Aphrodite Kapurniotu

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION（2025）

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Key words
alpha-synuclein,protein-protein interactions,(cross-)seeding,self-assembly,amyloid inhibitor
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