SPIRIT-DEFINE Explanation and Elaboration: Recommendations for Enhancing Quality and Impact of Early Phase Dose-Finding Clinical Trials Protocols
Moreno Ursino, Guillermo Villacampa,Jan Rekowski,Munyaradzi Dimairo,Olga Solovyeva,Deborah Ashby,Jordan Berlin,Oliver Boix,Melanie Calvert,An-Wen Chan, Courtney H. Coschi,Thomas R. Jeffry Evans,Elizabeth Garrett-Mayer,Robert M. Golub,Christina Guo,Kathryn S. Hayward,Sally Hopewell,John D. Isaacs,S. Percy Ivy,Thomas Jaki,Olga Kholmanskikh,Andrew Kightley,Shing Lee, Rong Liu, Adrian Mander, Lynley Marshall,James Matcham,Dhrusti Patel, Richard Peck,Khadija Rerhou Rantell,Dawn P. Richards, Mahtab Rouhifard, Lesley Seymour, Yoshiya Tanaka,Christopher J. Weir,Johann de Bono,Christina Yap ECLINICALMEDICINE（2025）
Key words
Early phase trials,Phase I,Dose-finding,Dose escalation/de-escalation,Protocol guidance,SPIRIT-DEFINE,SPIRIT
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper