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QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid-Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang,Kevin J. Thompson, Sunil Krishnan,Krishna R. Kalari,Karunya K. Kandimalla

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY(2024)

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Key words
Alzheimer's disease,blood-brain barrier,insulin resistance,modeling and simulation,pharmacodynamics
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