Design, Structure–Activity Relationships, and Computational Modeling Studies of a Series of Α-Helix Biased, Ultra-Short Glucagon-like Peptide-1 Receptor Agonists

Jonathon R. Sawyer, Joseph A. Audie,Jon Swanson,David Diller, Solimar Santiago,Valentin K. Gribkoff, Allison Ackerman,Victor J. Hruby,Gianpaolo Gobbo,Michael A. Bellucci, William A. Glauser, Brad L. Pentelute,Tomi K. Sawyer

MOLECULES（2025）

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Key words

glucagon-like peptide-1 (GLP-1),C alpha-methylation,<italic>p</italic>-phenyl-phenylalanine (Bip),2-amino-isobutyric acid (Aib),alpha-methyl-phenylalanine (alpha-MePhe),alpha-methyl-phenylalanine [2-F] (alpha-MePhe[2-F]),structure-activity relationship (SAR),quantitative structure-activity relationship (QSAR),structure-based design

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