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Discovery of Novel Low Bee-Toxicity Aphicidal Α-Butenolide: Design and Optimization Based on a Progressive Strategy of Acetylcholine Binding Protein and Calculated Oil-Water Partition Coefficient

Renxuan Zou,Xiang Li, Na Wang, Jinyang Zhou, Cong Wu,Mingjun Li, Xingxing Lu,Qing Han,Jiaxing Huang,Hongxia Duan

CHEMISTRY & BIODIVERSITY（2025）

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Key words
<italic>alpha</italic>-butenolide,ClogP,honeybee chimeric receptor AmeI<italic>alpha</italic>8/rat<italic>beta</italic>,low bee-toxicity,nAChR
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