Modulation of TCR Stimulation and Pifithrin-Α Improves the Genomic Safety Profile of CRISPR-engineered Human T Cells

Laurenz T. Ursch, Jule S. Mueschen, Julia Ritter,Julia Klermund, Bettina E. Bernard, Saskia Kolb,Linda Warmuth,Geoffroy Andrieux, Gregor Miller, Marina Jimenez-Munoz,Fabian J. Theis,Melanie Boerries,Dirk H. Busch,Toni Cathomen,Kathrin Schumann

CELL REPORTS MEDICINE（2024）

Cited 0|Views0

Key words

CRISPR engineering,human T cells,chromosomal aberrations,large deletions,aneuploidy,translocations,pifithrin-alpha,CAR T cell therapy,T cell activation,genomic integrity

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined