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High Throughput Application of the NanoBiT Biochemical Assay for the Discovery of Selective Inhibitors of the Interaction of PI3K-p110α with KRAS

Mohamed Ismail,Gareth Davies,Graham Sproat,Tiziana Monteverde,Jonathan Tart, Marta Acebron-Garcia-de-Eulate,Andrea Gohlke,David Hancock, Santosh Adhikari, Sandra Stefanovic-Barrett, David M. Smith,Vikki Flemington, Emma S. Gleave-Hanford,Geoffrey A. Holdgate,Jason G. Kettle,Julian Downward

SLAS Discovery（2024）

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关键词
PI 3-kinase,KRAS,NanoBiT assay,Drug discovery,Assay development,High throughput screening
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