Integrative Pathway Analysis Across Humans and 3D Cellular Models Identifies the P38 MAPK-MK2 Axis As a Therapeutic Target for Alzheimer’s Disease

Pourya Naderi Yeganeh,Sang Su Kwak,Mehdi Jorfi,Katjusa Koler, Thejesh Kalatturu,Djuna von Maydell, Zhiqing Liu, Kevin Guo,Younjung Choi,Joseph Park, Nelson Abarca,Grisilda Bakiasi,Murat Cetinbas,Ruslan Sadreyev,Ana Griciuc,Luisa Quinti,Se Hoon Choi,Weiming Xia,Rudolph E. Tanzi,Winston Hide,Doo Yeon Kim

NEURON（2025）

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Key words

Alzheimer’s disease,drug target discovery,tau pathology,3D human neuronal cell models,transcriptomics,phosphoproteomics,integrative analysis,pathway analysis,p38 MAP kinase,amyloid beta 42

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