Roscovitine, a CDK Inhibitor, Reduced Neuronal Toxicity of Mhtt by Targeting HTT Phosphorylation at S1181 and S1201 in Vitro

Hongshuai Liu, Ainsley Mccollum, Asvini Krishnaprakash, Yuxiao Ouyang, Tianze Shi,Tamara Ratovitski,Mali Jiang,Wenzhen Duan,Christopher A. Ross,Jing Jin

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES（2024）

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Huntington’s disease,roscovitine,CDK5,post-translational modification (PTM),toxicity

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