Exploring the Druggability of the UEV Domain of Human TSG101 in Search for Broad-Spectrum Antivirals

Fernando Montero, Marisa Parra-Lopez,Alejandro Rodriguez-Martinez,Javier Murciano-Calles,Pedro Buzon,Ziying Han, L. -y. Lin,Maria C. Ramos,Javier Ruiz-Sanz,Jose C. Martinez,Marco Radi,Christiane Moog,Sandra Diederich,Ronald N. Harty,Horacio Perez-Sanchez,Francisca Vicente,Francisco Castillo,Irene Luque

PROTEIN SCIENCE（2025）

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关键词

AlphaScreen,bimolecular complementation,broad-spectrum antivirals,cell-based antiviral assays,differential scanning fluorimetry,docking,ESCRT,high throughput screening,molecular dynamics,TSG101,UEV domain,viral late domains,virus budding

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