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Engineered Protein Subunit COVID19 Vaccine is As Immunogenic As Nanoparticles in Mouse and Hamster Models

Melissa M. Matthews,Tae Gyun Kim,Keon Young Kim,Vladimir Meshcheryakov, Higor Alves Iha,Miho Tamai,Daiki Sasaki, Paola Laurino, Saacnicteh Toledo-Patino,Mary Collins,Tzung-Yang Hsieh,Satoshi Shibata,Noriko Shibata,Fumiko Obata,Jun Fujii,Toshihiro Ito,Hiroshi Ito,Hiroki Ishikawa,Matthias Wolf

SCIENTIFIC REPORTS（2024）

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Key words
Protein subunit vaccine,Protein engineering,Scaffold,Adjuvant,Nanoparticle,SARS-CoV-2 (CoV-2) spike protein
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