Generation of a Nonbilayer Lipid Nanoenvironment after Epitope Binding Potentiates Neutralizing HIV-1 MPER Antibody

Sara Insausti, Ander Ramos-Caballero, Brian Wiley,Saul Gonzalez-Resines,Johana Torralba, Anne Elizaga-Lara, Christine Shamblin,Akio Ojida,Jose M. M. Caaveiro,Michael B. Zwick,Edurne Rujas,Carmen Domene,Jose L. Nieva

ACS APPLIED MATERIALS & INTERFACES（2024）

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Key words

antibody-membrane interaction,lipid nanoenvironment,membrane deformation,site-selective chemical modification,antibody engineering,HIV-1 antibody,moleculardynamics simulations,metadynamics

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