Synthesis and Structure-Activity Relationship of Covalent Inhibitors of Sars-Cov-2 Papain-Like Protease with Antiviral Potency

Catherine C. Rouch,Arnab K. Chatterjee, Connor Mccarty, Lirui Song, Alan Chu, Kristen Johnson, Mina Heacock,Laura Riva,Case W. Mcnamara,Karen C. Wolff,Rebecca Greene-Cramer, Anna De Falco,Gaetano T. Montelione, Gennadii A. Grabovyi

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2025）

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Key words

COVID-19,Antiviral,Papain-like protease,Covalent inhibitor,Structure-activity relationship,Pharmacokinetic,Fumarate ester

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