A Triple-Mismatch Differentiating Assay Exploiting Activation and Trans Cleavage of CRISPR-Cas12a for Mutation Detection with Ultra Specificity and Sensitivity

Yibo Hu,Yangwei Liao,Shutao Pan, Jingcong Zhou,Changqing Wan, Feiyang Huang, Yu Bai,Chen Lin, Qilong Xia, Zixi Liu,Jun Gong, Xiaoqi Nie,Min Wang,Renyi Qin

BIOSENSORS & BIOELECTRONICS（2025）

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Key words

CRISPR-Cas12a,Mutation detection,Liquid biopsy,Specificity,Sensitivity

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