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Development of an Orally Bioavailable CDK12/13 Degrader and Induction of Synthetic Lethality with AKT Pathway Inhibition

Yu Chang,Xiaoju Wang,Jianzhang Yang,Jean Ching-Yi Tien,Rahul Mannan, Gabriel Cruz,Yuping Zhang,Josh N. Vo,Brian Magnuson,Somnath Mahapatra,Hanbyul Cho,Saravana Mohan Dhanasekaran,Cynthia Wang,Zhen Wang,Licheng Zhou, Kaijie Zhou,Yang Zhou,Pujuan Zhang,Weixue Huang,Lanbo Xiao, Weihuang Raymond Liu, Rudana Hamadeh,Fengyun Su,Rui Wang,Stephanie J. Miner,Xuhong Cao,Yunhui Cheng,Rohit Mehra,Ke Ding,Arul M. Chinnaiyan

CELL REPORTS（2024）

引用 1|浏览33
关键词
CDK12,CDK13,AKT,proteolysis targeting chimera,PROTAC,synthetic lethality,prostate cancer,AKT inhibitors
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