An Overview of Interpretability of Two Models of Unbound Fraction That Are Used in Combination with the Well-Stirred Model for Predicting Hepatic Clearance of Drugs
Journal of Pharmaceutical Sciences（2024）
Key words
Albumin-mediated,Dynamic well-stirred model,DMPK,First-in-humans,In vitro-to-in vivo extrapolations,IVIVE,OATPs,PBPK modeling,Pharmacokinetics,Uptake
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