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Synthetic Lethality of Combined ULK1 Defection and P53 Restoration Induce Pyroptosis by Directly Upregulating GSDME Transcription and Cleavage Activation Through ROS/NLRP3 Signaling

Wei Chen,Kai-Bin Yang,Yuan-Zhe Zhang, Zai-Shan Lin,Jin-Wei Chen,Si-Fan Qi,Chen-Fei Wu,Gong-Kan Feng,Da-Jun Yang,Ming Chen,Xiao-Feng Zhu,Xuan Li

Journal of Experimental & Clinical Cancer Research（2024）

引用 1|浏览10
关键词
MDM2 inhibitor,Mitophagy,Pyroptosis,Reactive oxygen species,TP53,ULK1
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