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Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup Candidate

Julie L. Engers,Katrina A. Bollinger,Rory A. Capstick,Madeline F. Long,Aaron M. Bender,Jonathan W. Dickerson,Weimin Peng,Christopher C. Presley,Hyekyung P. Cho,Alice L. Rodriguez,Colleen M. Niswender,Sean P. Moran,Zixiu Xiang,Anna L. Blobaum,Olivier Boutaud,Jerri M. Rook,Darren W. Engers,P. Jeffrey Conn,Craig W. Lindsley

ACS CHEMICAL NEUROSCIENCE（2024）

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关键词
muscarinic acetylcholine receptor subtype 1 (M1),positive allosteric modulator (PAM),cognition,metabolism
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