Total Syntheses and Stereochemical Assignment of Acremolides A and B
Molecules(2024)
摘要
The absolute stereochemical configurations of acremolides A and B were predicted by a biochemistry-based rule and unambiguously confirmed through their total syntheses. The features of the total syntheses include sequential Krische’s Ir-catalyzed crotylation, Brown’s borane-mediated crotylation, Mitsunobu esterification reaction, and cross-metathesis reaction. The efficient total synthesis enabled clear validation of the predicted stereochemistry for acremolides A and B.
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关键词
total syntheses,natural products,asymmetric crotylation,acremolide
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