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Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Polymixin B1, B2, Ile-B1, E1, and E2 in Human Plasma and Its Clinical Pharmacokinetic Application

Dong Xiang,Ninghong Li, Guangjie Yang,Hengyi Yu,Xiping Li, Lihui Qiu, Yufei Chen,Lu Liu,Xuepeng Gong

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS(2024)

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Key words
Polymyxin B,Polymyxin E,LC-MS/MS,Pharmacokinetic study,Method development
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