Development and Characterization of Biocompatible Cellulose Acetate Substrate for Flexible Electrochemical Biosensors
IEEE Journal on Flexible Electronics(2024)
Abstract
This paper focuses on the development and characterization of flexible, biocompatible substrates using Cellulose Acetate (CA), a natural biopolymer known for its biocompatibility and adjustable biodegradability. As proof of concept, electrochemical detection of
Staphylococcus aureus
was carried out using Au-nanoparticle modified Flexible Screen-Printed Electrode (FSPE) on the CA substrate. The key take away from the reliability studies is that the electrochemical performance is intact after multiple bending’s. Tensile strength of 2.75 +/-0.03 MPa is an indicative of the flexibility of the substrate. The substrate showed little degradation during the fabrication of SPE and the time-consuming surface functionalization protocols required for Au-nanoparticle deposition and bioreceptor immobilization. The selective and ultrasensitive detection of
S. aureus
(LOD: 0.13 CFU/mL) is a testimony for the robustness of the substrate in flexible electrochemical biosensor applications.
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Key words
Bacterial detection,Cellulose acetate,Electrochemical sensor,Flexible screen-printed electrode,Staphylococcus aureus,Toll-like receptor
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