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Identification of the Clinical Candidate PF-07284890 (ARRY-461), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer.

Li Ren,David Moreno,Brian R. Baer, Patrick Barbour, Tanna Bettendorf,Karyn Bouhana, Karin Brown,Suzy A. Brown,Jay B. Fell,Dylan P. Hartley,Erik J. Hicken,Ellen R. Laird,Patrice Lee, Joseph Mccown,Jennifer N. Otten, Brett Prigaro,Ross Wallace, Dean Kahn

JOURNAL OF MEDICINAL CHEMISTRY（2024）

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