Exploring Monocyclic Core: Discovery of Pyrrol-2-one Derivatives As a New Series of Potent MCHR1 Antagonists with in Vivo Efficacy

Murugaiah A. M. Subbaiah, Umasankar Mandal, Vidya Patankar, Selvakumar Bhaskaran, Ravikumar Nutakki, Bhadresh Rami,Devang Praful Shah, Shahe Mahammad,Brian J. Murphy,Christine Huang,Jeffrey A. Robl,William N. Washburn

European Journal of Medicinal Chemistry（2024）

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Key words

Melanin-concentrating hormone,MCHR1,Antagonists,Pyrrol-2-one,Anti-obesity,Off-rate,CNS

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