A signal-on electrochemiluminescence (ECL) sensor based on luminol@carbon nanotubes and CdTe-ZnS@hydroxyapatite for the detection of paclitaxel

A signal-on solid-state electrochemiluminescence (ECL) sensor based on luminol@carbon nanotubes (luminol@CNTs) and CdTe-ZnS@hydroxyapatite (CdTe-ZnS@HAP) was constructed for the detection of paclitaxel (PTX). In this sensing platform, luminol was used as the main luminophore and CdTe-ZnS was used as a co-reaction accelerator. CNTs and HAP were acted as carriers to adsorb more luminophores and co-reaction promoters. In addition, due to the enhanced effect of PTX on the ECL intensity of the luminol-O2 system, PTX was introduced as the final detection target. Under the optimal experimental conditions, the ECL intensity change values (ΔI) of the sensor showed a good linear relationship with the logarithm of PTX concentration in the range of 3 × 10-12 − 3 × 10-7 molL-1, and the limit of detection was 1 × 10-12 mol L-1(S/N = 3). This method was successfully applied to the determination of trace PTX concentration in serum.