Scalable Synthesis of ABBV-105 Enabled by Suzuki Coupling with Low Pd Loading, Ru-Catalyzed Asymmetric Hydrogenation, and Acylation Using Impinging Jet Benoit Cardinal-David , Shashank Shekhar , Eric M. Phillips , Elizabeth C. Swift , Brian Kotecki , Andrew R. Ickes , Gregory E. Storer , Daniel D. Caspi , Anuj Verma , Eric G. Moschetta , Daniel Tao , Westin H. Morrill , John R. Bellettini , Fredrik L. Nordstrom , Alessandra Mattei , Kirsten Springer , Haixiao Qiu , Jeffrey T. Bien , Onkar Manjrekar , Rodger F. Henry , Grier A. Wallace , Lisa Schaffter , Eric A. Voight ORGANIC PROCESS RESEARCH & DEVELOPMENT（2024）
关键词
BTK Inhibitor, Suzuki coupling, enantioselectivehydrogenation, impinging jet, acrylamide
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