Case series of Li-Fraumeni syndrome: carcinogenic mechanisms in breast cancer with TP53 pathogenic variant carriers

Mari Hosonaga,Eri Habano,Hiromi Arakawa,Keika Kaneko, Takeshi Nakajima,Naomi Hayashi,Ippei Fukada, Akira Nakamura,Yurie Haruyama,Tetsuyo Maeda,Hitoshi Inari,Takayuki Kobayashi, Eri Nakashima, Takayuki Ueno, Toshimi Takano,Shunji Takahashi, Shinji Ohno,Arisa Ueki

Breast Cancer（2024）

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摘要

Li-Fraumeni syndrome (LFS), a hereditary condition attributed to TP53 pathogenic variants,(PV), is associated with high risks for various malignant tumors, including breast cancer. Notably, individuals harboring TP53 PVs are more likely (67–83

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关键词

Li-Fraumeni syndrome,TP53,Breast cancer,Hormone receptor,Human epidermal growth factor receptor 2

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