Rare Coronary Artery Variants are Associated with Increased Mortality and Reinterventions Following the Arterial Switch Operation
The Journal of Thoracic and Cardiovascular Surgery(2024)
Abstract
Objective
To determine the influence of coronary anatomy on long-term outcomes of the arterial switch operation (ASO).
Methods
We retrospectively reviewed patients with transposition of the great arteries or Taussig-Bing anomaly who underwent ASO at our institution between 1992 and 2022. The primary endpoint was freedom from a composite of death, transplant, or coronary reintervention.
Results
A total of 632 patients (median age: 5.0 days [IQR, 4.0-7.0]) underwent ASO. Coronary anatomy included: usual (n=411, 65%), circumflex from sinus 2 (n=89, 14%), inverted (n=55, 9%), single sinus (n=46, 7%), and intramural (n=31, 5%). Overall operative mortality was 3% (n=16) and highest among intramurals (n=3, 10%), though dropped to 0% in this group in the most recent decade. Median follow-up was 14.5 years [IQR, 6.0-20.3]. Twenty-year freedom from the primary endpoint was 95%±1% for usual anatomy, 99%±1% for circumflex from sinus 2, 90%±4% for inverted, 91%±4% for single sinus, and 80%±9% for intramural (P<0.001). Intramurals had the highest 20-year incidence of coronary reintervention (11%±8%). Cox modeling identified intraoperative coronary revision (HR 20.1, 95% CI:[9.4-53.9], P<0.001), Taussig-Bing anomaly (HR 4.9, 95% CI:[2.2-10.9], P<0.001), and an intramural coronary artery (HR 2.9, 95% CI: [1.0-8.2], P=0.04) to be risk factors for the composite endpoint.
Conclusions
Rare coronary artery variants—particularly intramural—are associated with increased mortality and coronary reinterventions after ASO. A low threshold for unroofing intramurals is likely associated with declining mortality and improved outcomes. Additional investigations are required to determine the long-term fate of the coronary arteries after ASO.
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Key words
arterial switch operation,ASO,transposition of the great arteries,intramural coronary arteries
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