Fluid Management for Sepsis-Induced Hypotension in Patients with Advanced Chronic Kidney Disease: a Secondary Analysis of the CLOVERS Trial
Critical Care(2024)
Abstract
Early fluid management in patients with advanced chronic kidney disease (CKD) and sepsis-induced hypotension is challenging with limited evidence to support treatment recommendations. We aimed to compare an early restrictive versus liberal fluid management for sepsis-induced hypotension in patients with advanced CKD. This post-hoc analysis included patients with advanced CKD (eGFR of less than 30 mL/min/1.73 m2 or history of end-stage renal disease on chronic dialysis) from the crystalloid liberal or vasopressor early resuscitation in sepsis (CLOVERS) trial. The primary endpoint was death from any cause before discharge home by day 90. Of 1563 participants enrolled in the CLOVERS trial, 196 participants had advanced CKD (45
MoreTranslated text
Key words
Bacteremia,Septic shock,Hypervolemia,Vasopressor,Chronic kidney disease,Dialysis
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined