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Natural Carriage of Streptococcus Pneumoniae is Associated with Increased Experimental Pneumococcal Carriage but Reduced Conjugate Vaccine Efficacy in a Human Challenge Model

Bridgette Galafa,Tarsizio Chikaonda,Evaristar Kudowa,Simon Sichone,Lusako Sibale,Faith Thole,Christopher Mkandawire,Dingase Dula,Edna Nsomba,Godwin Tembo,Mphatso Chaponda,Anthony E. Chirwa,Vitumbiko Nkhoma,Clara Ngoliwa,Raphael Kamng'ona,Neema Toto,Lumbani Makhaza,Alfred Muyaya,Ashleigh Howard,Tinashe K. Nyazika,John Ndaferankhande,Lorensio Chimgoneko,Ndaziona P. K. Banda,Gift Chiwala,Jamie Rylance,Daniela Ferreira,Kondwani C. Jambo,Ben Morton,Marc Y. R. Henrion,Stephen B. Gordon

JOURNAL OF INFECTIOUS DISEASES（2024）

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Key words
Africa,human challenge model,pneumococcal carriage,pneumococcus,vaccine efficacy
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