Managing SVC Syndrome in Patients with Cardiac Implantable Electronic Device Leads: Strategies and Considerations

Background Data on Transvenous (TV) lead-associated superior vena cava (SVC) syndrome are limited. The management of this problem might require a multidisciplinary approach, often involving TV lead extraction (TLE) followed by angioplasty and stenting. Objective To describe the management and outcome of TV lead-associated SVC syndrome Methods We retrospectively identified patients with a diagnosis of SVC syndrome and TV leads at Emory Healthcare between 2015 and 2023. Results 15 patients with lead-related SVC syndrome were identified. The cohort average age was 50 years. Symptoms included swelling in the face, neck, and upper extremity (67%), shortness of breath (53%) and lightheadedness (40%). Patients had on average 2 ± 0.7 leads crossing the SVC with a lead dwell time of 9.8 ± 7.5 years. Thirteen patients were managed with transvenous lead extraction (TLE), followed by SVC stenting and angioplasty (10), angioplasty alone (2), while one patient had no intervention after TLE. One patient was managed with anticoagulation, and another had angioplasty and stenting with lead jailing. One patient experienced SVC perforation and cardiac tamponade during SVC stenting managed successfully with a covered stent and pericardiocentesis. Among the 12 patients with TLE and angioplasty ± stenting, 7 patients underwent reimplantation of a transvenous lead. Two of those patients had symptoms recurrence and none of the 5 patients without lead reimplantation had recurrence of symptoms. Conclusion Lead-related SVC syndrome management requires a multidisciplinary approach often including TLE followed by angioplasty and stenting. Avoiding TV lead reimplantation might help reduce symptoms recurrence.