STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy

Emanuela Pessolano, Zlata A. Sosic,Armando A. Genazzani

Cell Calcium（2024）

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摘要

Two recent papers have highlighted that STIM1, a key component of Store-operated Ca2+-entry, is able to translocate to the nucleus and participate in nuclear Ca2+-handling and in DNA repair. These finding opens new avenues on the role that this Ca2+-sensing protein may have in health and disease.

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关键词

Store-operated calcium-entry,STIM1,Nuclear calcium, Tubular aggregate myopathy,ORAI1,DNA repair

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