Spectral Brain Graph Neural Network for Prediction of Anxiety in Children with Autism Spectrum Disorder
arxiv(2024)
Abstract
Children with Autism Spectrum Disorder (ASD) frequently exhibit comorbid
anxiety, which contributes to impairment and requires treatment. Therefore, it
is critical to investigate co-occurring autism and anxiety with functional
imaging tools to understand the brain mechanisms of this comorbidity.
Multidimensional Anxiety Scale for Children, 2nd edition (MASC-2) score is a
common tool to evaluate the daily anxiety level in autistic children.
Predicting MASC-2 score with Functional Magnetic Resonance Imaging (fMRI) data
will help gain more insights into the brain functional networks of children
with ASD complicated by anxiety. However, most of the current graph neural
network (GNN) studies using fMRI only focus on graph operations but ignore the
spectral features. In this paper, we explored the feasibility of using spectral
features to predict the MASC-2 total scores. We proposed SpectBGNN, a
graph-based network, which uses spectral features and integrates graph spectral
filtering layers to extract hidden information. We experimented with multiple
spectral analysis algorithms and compared the performance of the SpectBGNN
model with CPM, GAT, and BrainGNN on a dataset consisting of 26 typically
developing and 70 ASD children with 5-fold cross-validation. We showed that
among all spectral analysis algorithms tested, using the Fast Fourier Transform
(FFT) or Welch's Power Spectrum Density (PSD) as node features performs
significantly better than correlation features, and adding the graph spectral
filtering layer significantly increases the network's performance.
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