A High-Affinity, Cis-on Photoswitchable Beta Blocker to Optically Control Β2-Adrenergic Receptors in Vitro and in Vivo

Shuang Shi,Yang Zheng,Joelle Goulding,Silvia Marri,Laura Lucarini, Benjamin Konecny,Silvia Sgambellone,Serafina Villano,Reggie Bosma,Maikel Wijtmans,Stephen J. Briddon,Barbara A. Zarzycka,Henry F. Vischer,Rob Leurs

BIOCHEMICAL PHARMACOLOGY（2024）

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Key words

GPCR signalling,Molecular modelling,Site-directed mutagenesis,Rabbit intraocular pressure,beta(2)AR,Photoswitchable beta-blockers,GPCR signalling,Molecular modelling,Site-directed mutagenesis,Rabbit intraocular pressure

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